DESeq2 Results
Identifier Base Mean log2 Fold Change Standard Error p-value Adjusted p-value
hsa-miR-1224-5p 7.393 -0.631 0.4607 0.1708 0.5704
hsa-miR-134-5p 83.7 -0.4899 0.3351 0.1437 0.5125
hsa-miR-452-5p 10.46 0.4572 0.2874 0.1117 0.4626
hsa-miR-210-3p 551 -0.4386 0.2681 0.1019 0.4444
hsa-miR-221-5p 4.931 0.8585 0.3733 0.02147 0.2049
hsa-miR-6875-5p 0.7187 -1.001 0.5153 0.05204 0.332
hsa-miR-219a-5p 5.994 0.8331 0.4433 0.06022 0.3591
hsa-miR-6810-5p 1.091 1.068 0.6018 0.07604 0.3844
hsa-miR-129-5p 9.54 0.8414 0.3896 0.03081 0.2286
hsa-miR-6502-5p 0.7009 -0.9543 0.5213 0.06713 0.3768
hsa-miR-942-5p 14.83 -0.9793 0.2849 0.0005865 0.06944
hsa-miR-887-3p 9.309 0.8143 0.3544 0.02159 0.2049
hsa-miR-125b-1-3p 41.69 0.5049 0.3051 0.09793 0.4434
hsa-miR-4775 0.8446 -0.9913 0.5619 0.07771 0.3844
hsa-miR-211-5p 8.737 0.7204 0.4024 0.0734 0.3827
hsa-miR-362-3p 1.582 0.6745 0.3601 0.06105 0.3607
hsa-miR-3591-5p 0.7637 0.9494 0.4988 0.05701 0.3531
hsa-miR-375 713.7 -0.6971 0.3104 0.0247 0.2101
hsa-miR-30a-3p 263.4 0.7549 0.3126 0.01576 0.1971
hsa-miR-374a-5p 4.592 0.6952 0.4439 0.1173 0.4767
hsa-miR-148b-3p 588.6 0.4778 0.2972 0.1078 0.4547
hsa-miR-30d-3p 21.87 0.4031 0.2354 0.08688 0.4106
hsa-miR-4787-3p 0.7661 0.853 0.478 0.07438 0.3827
hsa-miR-885-3p 1.53 0.8915 0.4562 0.05069 0.3267
hsa-miR-4732-5p 7.669 -0.8862 0.3829 0.02064 0.2049
hsa-miR-22-5p 20.71 0.4997 0.2452 0.04156 0.2762
hsa-miR-1298-5p 135.6 0.6152 0.4212 0.1441 0.5125
hsa-miR-152-3p 49.05 0.7342 0.3151 0.01978 0.2049
hsa-miR-151a-3p 3413 0.2651 0.1442 0.06608 0.3764
hsa-miR-1273h-5p 1.284 -1.33 0.5422 0.01415 0.1961
hsa-miR-30b-5p 45.8 1.014 0.327 0.001928 0.09699
hsa-miR-3200-5p 1.047 -1.415 0.468 0.002496 0.09699
hsa-miR-181b-5p 400.4 0.5209 0.2196 0.01767 0.1997
hsa-miR-378g 53.43 -0.6685 0.3231 0.03856 0.2645
hsa-miR-193a-5p 46.46 -0.4178 0.3142 0.1836 0.5888
hsa-miR-485-3p 1.23 0.654 0.453 0.1488 0.5188
hsa-miR-425-3p 36.29 0.387 0.2163 0.07364 0.3827
hsa-miR-4739 1.211 0.8342 0.5834 0.1527 0.5296
hsa-miR-1-3p 5.651 -0.7039 0.4854 0.147 0.5181
hsa-miR-6515-5p 3.315 0.5823 0.3735 0.119 0.478
hsa-miR-4745-5p 1.648 -1.281 0.4668 0.006055 0.1486
hsa-miR-6852-5p 31.74 0.7805 0.3498 0.02564 0.2152
hsa-miR-708-3p 2.136 1.049 0.4594 0.02245 0.2049
hsa-miR-15a-5p 329.1 -0.5198 0.2646 0.04948 0.3221
hsa-miR-551a 0.9703 -0.5721 0.3865 0.1389 0.5086
hsa-miR-19b-3p 748.3 0.5217 0.3265 0.11 0.4588
hsa-miR-30c-5p 88 0.4317 0.2508 0.0852 0.4106
hsa-miR-16-2-3p 134.7 -1.15 0.2908 7.678e-05 0.03521
hsa-miR-320e 6.135 1.074 0.4238 0.01129 0.1961
hsa-miR-574-5p 4.997 0.565 0.3459 0.1024 0.4444
hsa-miR-125a-3p 6.692 0.9273 0.3852 0.01606 0.1971
hsa-miR-320b 1778 0.9674 0.3387 0.004287 0.1365
hsa-miR-363-3p 482.9 -0.6516 0.2529 0.009979 0.1961
hsa-miR-664a-3p 2.802 0.5615 0.4143 0.1753 0.5751
hsa-miR-421 45.26 -0.2324 0.1696 0.1707 0.5704
hsa-miR-122-5p 13700 -0.6061 0.412 0.1412 0.5097
hsa-miR-1269a 1.462 -0.9656 0.5524 0.08045 0.3948
hsa-miR-25-5p 18.05 -0.5214 0.2809 0.06345 0.3675
hsa-miR-550a-3p 3.473 -0.7382 0.431 0.08673 0.4106
hsa-miR-181c-5p 103.4 0.5471 0.2394 0.0223 0.2049
hsa-miR-93-5p 483.9 -0.4945 0.2183 0.02348 0.2051
hsa-miR-23b-3p 89.91 0.7677 0.2754 0.005316 0.1475
hsa-miR-486-3p 226.5 -0.6613 0.2869 0.02116 0.2049
hsa-miR-3913-5p 3.522 0.7888 0.3053 0.009769 0.1961
hsa-miR-326 43.02 0.8893 0.2996 0.002996 0.1006
hsa-miR-30c-2-3p 8.333 0.7937 0.3511 0.02378 0.2051
hsa-miR-219a-2-3p 9.736 0.9796 0.5197 0.05944 0.3578
hsa-miR-128-3p 70.26 -0.4468 0.1866 0.01662 0.1997
hsa-miR-4772-5p 0.8825 -0.9237 0.4872 0.05797 0.3556
hsa-miR-143-5p 1.046 1.464 0.4858 0.002589 0.09699
hsa-miR-504-5p 0.7199 1.394 0.46 0.002439 0.09699
hsa-miR-335-3p 8.797 0.5293 0.3458 0.1259 0.4843
hsa-miR-145-3p 24.26 0.6089 0.2927 0.03752 0.2637
hsa-miR-370-3p 13.05 1.08 0.3854 0.005085 0.1475
hsa-miR-92a-3p 9578 -0.5361 0.247 0.02997 0.2286
hsa-miR-1294 12.81 -1.203 0.3112 0.0001104 0.03521
hsa-miR-338-3p 15.9 0.4208 0.2848 0.1395 0.5086
hsa-miR-4664-3p 0.5814 -1.222 0.5328 0.02185 0.2049
hsa-miR-128-1-5p 4.733 0.5371 0.2772 0.05262 0.3324
hsa-miR-182-5p 1657 -0.7524 0.29 0.009475 0.1961
hsa-miR-451a 12270 -0.6311 0.2663 0.0178 0.1997
hsa-miR-874-3p 91.61 -0.3589 0.2687 0.1816 0.5851
hsa-miR-376c-3p 2.344 1.162 0.4482 0.009552 0.1961
hsa-miR-200c-3p 1.459 -1.001 0.4619 0.03018 0.2286
hsa-miR-1292-5p 0.9361 -0.5484 0.4051 0.1758 0.5751
hsa-miR-376a-3p 0.8187 0.7396 0.491 0.132 0.4954
hsa-miR-103a-3p 1688 -0.3368 0.2046 0.09972 0.4444
hsa-miR-1976 0.9717 -0.7738 0.4473 0.08365 0.4074
hsa-miR-369-5p 1.396 -0.83 0.4705 0.07773 0.3844
hsa-miR-548w 0.7229 0.9715 0.535 0.06941 0.381
hsa-miR-296-5p 4.13 -0.7906 0.41 0.05386 0.3369
hsa-miR-106a-5p 4.202 -0.8241 0.339 0.01506 0.1961
hsa-let-7g-5p 451.3 -0.5684 0.2278 0.01259 0.1961
hsa-miR-146a-5p 4513 0.8107 0.2379 0.000653 0.06944
hsa-miR-127-5p 4.965 0.8962 0.395 0.02328 0.2051
hsa-miR-760 10.33 0.8252 0.3305 0.01254 0.1961
hsa-let-7a-3p 7.612 0.5162 0.3538 0.1446 0.5125
hsa-miR-584-5p 124.7 -0.3459 0.2314 0.1349 0.4976
hsa-miR-3120-3p 0.6282 0.6808 0.4229 0.1074 0.4547
hsa-miR-6842-3p 13.64 0.533 0.3259 0.102 0.4444
hsa-miR-204-5p 11390 1.396 0.3933 0.0003844 0.06132
hsa-miR-1270 2.672 -0.7309 0.3926 0.06263 0.3666
hsa-miR-365b-5p 1.838 1.218 0.4991 0.0147 0.1961
hsa-let-7c-5p 322.5 0.3724 0.2782 0.1806 0.5849
hsa-miR-4646-5p 7.232 -0.7931 0.5294 0.1341 0.4974
hsa-miR-132-3p 11.11 0.4151 0.2563 0.1053 0.4539
hsa-miR-329-3p 1.05 0.8 0.4763 0.093 0.43
hsa-miR-28-5p 36.65 0.5782 0.2677 0.03078 0.2286
hsa-miR-181a-2-3p 57.1 0.7173 0.2241 0.001368 0.07935
hsa-miR-181a-5p 9439 0.5312 0.2032 0.008962 0.1961
hsa-miR-431-3p 1.627 0.7023 0.4515 0.1199 0.478
hsa-miR-188-5p 1.581 0.8043 0.3901 0.03922 0.2662
hsa-miR-550a-3-5p 0.6505 -0.957 0.3879 0.01363 0.1961
hsa-miR-5683 1.327 1.367 0.4487 0.002311 0.09699
hsa-miR-1246 23.77 0.8361 0.4133 0.04308 0.2833
hsa-miR-1180-3p 43.03 -0.4568 0.3048 0.1339 0.4974
hsa-miR-30e-3p 140 0.4094 0.2629 0.1194 0.478
hsa-let-7b-5p 1634 -0.3396 0.2078 0.1023 0.4444
hsa-miR-183-5p 116.4 -0.4984 0.2923 0.08816 0.4136
hsa-miR-34c-3p 3.005 1.444 0.5081 0.004493 0.1365
hsa-miR-130b-3p 264 0.5858 0.2433 0.01605 0.1971
hsa-miR-196a-5p 2.327 -1.266 0.5194 0.01481 0.1961
hsa-miR-496 0.6696 -1.208 0.5228 0.02087 0.2049
hsa-miR-1307-5p 249.6 0.6954 0.3202 0.02991 0.2286
hsa-miR-124-3p 7.23 1.277 0.5114 0.01254 0.1961
hsa-miR-373-3p 0.6099 0.7495 0.4899 0.126 0.4843
hsa-miR-210-5p 0.6011 0.8062 0.4742 0.08915 0.4152
hsa-miR-484 218.3 -0.4871 0.2702 0.07145 0.3827
hsa-miR-1538 2.71 -0.9277 0.4088 0.02326 0.2051
hsa-miR-216a-5p 1.077 1.149 0.5202 0.02713 0.2248
hsa-miR-190b 2.988 -0.5614 0.3689 0.128 0.4843
hsa-miR-2115-3p 1.23 1.039 0.424 0.01422 0.1961
hsa-miR-3691-5p 4.358 -1.436 0.4784 0.002677 0.09699
hsa-let-7f-1-3p 2.28 0.6087 0.4366 0.1633 0.5571
hsa-miR-30a-5p 4523 0.4863 0.3168 0.1248 0.4843
hsa-miR-25-3p 4723 -0.3382 0.2106 0.1083 0.4547
hsa-miR-1255a 0.5808 -0.8258 0.5032 0.1008 0.4444
hsa-miR-154-5p 0.868 0.828 0.483 0.08651 0.4106
hsa-miR-16-5p 5836 -0.6138 0.2811 0.029 0.2286
hsa-mir-378c 177.5 -1.032 0.3154 0.001073 0.07569
hsa-miR-195-5p 52.94 1.309 0.3923 0.0008504 0.07569
hsa-miR-3605-5p 19.66 -0.6472 0.274 0.0182 0.2002
hsa-miR-181c-3p 37.39 0.6505 0.285 0.02248 0.2049
hsa-miR-100-5p 1538 0.6845 0.3209 0.03294 0.2416
hsa-miR-5100 1.23 0.8955 0.5869 0.1271 0.4843
hsa-miR-10a-5p 8851 0.5078 0.2878 0.07769 0.3844
hsa-miR-5588-5p 3.989 0.8908 0.3849 0.02063 0.2049
hsa-miR-151a-5p 11.04 0.755 0.3039 0.01297 0.1961
hsa-miR-7706 92.71 -0.4064 0.2966 0.1707 0.5704
hsa-miR-34c-5p 139.8 0.5465 0.386 0.1568 0.5409
hsa-miR-143-3p 8321 0.4653 0.2566 0.06986 0.381
hsa-miR-561-5p 0.6545 -0.9196 0.4412 0.03711 0.2637
hsa-miR-181d-5p 28.39 0.9719 0.2652 0.0002479 0.05272
hsa-miR-3677-3p 7.412 0.7853 0.3127 0.01202 0.1961
hsa-miR-96-5p 13.82 -0.9367 0.3402 0.005907 0.1486
hsa-miR-2355-3p 0.7897 1.004 0.409 0.01408 0.1961
hsa-miR-19a-3p 123.9 0.4622 0.3366 0.1696 0.5704
hsa-miR-378f 11.62 0.4641 0.2957 0.1166 0.4767
hsa-miR-215-5p 131.8 -0.7293 0.3987 0.06733 0.3768
hsa-miR-1262 0.8335 -0.688 0.5048 0.1729 0.5717
hsa-miR-499a-5p 7.47 -0.7065 0.4003 0.07759 0.3844
hsa-miR-125a-5p 345.9 -0.7815 0.3095 0.01157 0.1961
hsa-miR-26a-5p 2931 0.7201 0.2847 0.01142 0.1961
hsa-miR-3187-3p 1.41 -0.9994 0.477 0.03617 0.2622
hsa-miR-144-5p 90.74 -0.6765 0.2886 0.01906 0.2049
hsa-miR-4440 1.121 1.188 0.5731 0.03816 0.2645
hsa-miR-550a-3-5p|hsa-miR-550a-5p 9.273 -0.7003 0.2781 0.01179 0.1961
hsa-let-7g-3p 4.186 -0.5241 0.3724 0.1593 0.5463
hsa-miR-4433b-5p 9.125 0.6577 0.3975 0.09799 0.4434
hsa-miR-671-5p 11.67 0.7571 0.4156 0.06846 0.3798
hsa-miR-664a-5p 5.934 0.6487 0.265 0.01438 0.1961
hsa-miR-296-3p 4.338 0.9331 0.3939 0.01784 0.1997
hsa-miR-101-5p 4.391 0.715 0.3498 0.04097 0.2752
hsa-miR-3620-3p 0.6456 -1.064 0.4917 0.03052 0.2286
hsa-miR-486-5p 533100 -0.4024 0.2993 0.1788 0.582
hsa-miR-27b-5p 10.93 0.4151 0.2303 0.07148 0.3827
hsa-miR-181a-3p 33.41 0.373 0.2381 0.1172 0.4767
hsa-miR-320a 16900 0.5296 0.3191 0.09698 0.4434
hsa-miR-107 1272 -0.4243 0.237 0.07339 0.3827
hsa-miR-184 4.707 0.9118 0.4191 0.02957 0.2286
hsa-miR-199a-5p 50.2 0.8534 0.2849 0.002737 0.09699
hsa-miR-214-3p 6.164 0.7393 0.3556 0.03761 0.2637
hsa-miR-28-3p 1561 0.4352 0.1834 0.01766 0.1997
hsa-miR-6503-3p 7.263 -1.048 0.3788 0.00566 0.1486
hsa-miR-1228-5p 1.322 -0.7585 0.5554 0.1721 0.5717
hsa-miR-99a-5p 449.4 0.5476 0.3068 0.07423 0.3827
hsa-miR-29c-5p 6.263 0.4193 0.3165 0.1852 0.5908
hsa-miR-18b-5p 0.5481 -0.7968 0.5418 0.1414 0.5097
hsa-miR-3180|hsa-miR-3180-3p 6.495 -0.5972 0.3916 0.1272 0.4843
hsa-miR-191-5p 6486 0.3068 0.1991 0.1234 0.4843
hsa-miR-335-5p 45.09 0.4674 0.2896 0.1066 0.4547
hsa-miR-145-5p 42.24 0.8512 0.2626 0.001186 0.07569
hsa-miR-205-5p 34.81 0.99 0.3699 0.007439 0.1758
hsa-let-7b-3p 14.78 0.5383 0.2906 0.06394 0.3675
hsa-miR-197-5p 2.679 -0.5934 0.411 0.1487 0.5188
hsa-miR-186-3p 1.136 0.6805 0.4474 0.1283 0.4843
hsa-miR-1299 14.22 -0.5891 0.3826 0.1236 0.4843
hsa-miR-4446-3p 13.19 1.122 0.3403 0.0009817 0.07569
hsa-let-7d-5p 110 -0.4129 0.2184 0.05867 0.3565
hsa-miR-15b-3p 28.03 -0.7064 0.321 0.02775 0.227

Understanding Your Results

The table above displays differentially expressed miRNAs for selected Atlas data.
  • The Checkbox column allows you to select a given miRNA for further downstream analysis.
    You can click the checkbox in the upper left corner of the table to select all visible miRNAs.
  • The Identifiers column contains all of your miRNA identifiers.
  • The Base Mean column contains "the average of the normalized count values, divided by the size factors, taken over all samples [in the original dataset]" for each miRNA.[1]
  • The log2 Fold Change column contains the "effect size estimate" for each miRNA.[1]
  • The Standard Error column contains the "standard error estimate for the log2 fold change estimate" for each miRNA.[1]
  • The p-value column contains the Wald test p-value for each miRNA.[1]
  • The Adjusted p-value column contains the Benjamini-Hochberg adjusted p-value for each miRNA.[1]
By default, the table is sorted by adjusted p-value, but you can sort by any of the columns.

Downstream Analysis

When you have selected your miRNAs of interest (via the checkboxes on the left side of the table),
you can perform downstream analyses by clicking the "Analyze Selected miRNAs" button above the table.

See descriptions of all available downstream analysis tools below.

Pathway Finder
  • Use Pathway Finder (hosted by WikiPathways) to find pathways containing miRNAs of interest (or protein targets of those miRNAs).
  • Click a given pathway title to visualize its contents at the bottom of the page.
  • Then, select a given miRNA to highlight its associated target(s).
  • The pathway visualization is interactive - zoom in or out by using the + and - icons, and click a given gene product to learn more about it.
  • Designed and implemented by Kristina Hanspers, Anders Riutta, and Alexander Pico at the Gladstone Institutes, San Francisco, CA.
  • Integrated into the exRNA Atlas by William Thistlethwaite and Neethu Shah at the Bioinformatics Research Lab, Baylor College of Medicine, Houston, TX.

References

[1] Love, M. I., Anders, S., Kim V., & Huber W. (2017, Aug 9). RNA-seq workflow: gene-level exploratory analysis and differential expression. Retrieved from http://www.bioconductor.org/help/workflows/rnaseqGene/
DESeq2 designed and implemented by Michael Love, Simon Anders, and Wolfgang Huber (PubMed).
DESeq2 integrated into the exRNA Atlas by William Thistlethwaite and Neethu Shah at the Bioinformatics Research Lab, Baylor College of Medicine, Houston, TX.